The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat

The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat

Lipoprotein(a) [Lp(a)] concentrations are regulated by the LPA gene mainly via the large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early studies suggested an effect of long pentanucleotide repeat (PNR) alleles (10 and 11 repeats, PNR10 and PNR11) in the LPA promot...

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Bibliographic Details
Main Authors: Rebecca Grüneis, Hansi Weissensteiner, Claudia Lamina, Sebastian Schönherr, Lukas Forer, Silvia Di Maio, Gertraud Streiter, Annette Peters, Christian Gieger, Florian Kronenberg, Stefan Coassin
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Lipid Research
Subjects:
lipoprotein(a)
lipoprotein(a) metabolism
apolipoproteins
genomics
lipoproteins
apolipoprotein(a)
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522001390

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http://www.sciencedirect.com/science/article/pii/S0022227522001390

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