Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer

Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer

Abstract Background Aggregated amyloid-β peptide 1–42 (Aβ42), derived from the cellular amyloid precursor protein, is one of the pathological hallmarks of Alzheimer’s disease (AD). Although active immunization against Aβ42 peptide was successful in AD mouse models and led to removal of plaques and i...

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Bibliographic Details
Main Authors: Doris Lambracht-Washington, Min Fu, Pat Frost, Roger N. Rosenberg
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Immunotherapy
Nonhuman primates
DNA vaccination
Amyloid-β
Antibody response
Online Access:http://link.springer.com/article/10.1186/s13195-017-0257-7

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http://link.springer.com/article/10.1186/s13195-017-0257-7

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