Factors Influencing the Crystallization-Onset Time of Metastable ASDs

Factors Influencing the Crystallization-Onset Time of Metastable ASDs

In formulation development, amorphous solid dispersions (ASD) are considered to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). However, the crystallization of APIs often limits long-term stability and thus the shelf life of ASDs. It has already been sho...

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Bibliographic Details
Main Authors: Friederike Wolbert, Ineke-Katharina Fahrig, Tobias Gottschalk, Christian Luebbert, Markus Thommes, Gabriele Sadowski
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceutics
Subjects:
amorphous solid dispersion
hot-melt extrusion
spray drying
stability
water sorption
PC-SAFT
Online Access:https://www.mdpi.com/1999-4923/14/2/269

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https://www.mdpi.com/1999-4923/14/2/269

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