Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum

Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum

Abstract Malaria genomic surveillance often estimates parasite genetic relatedness using metrics such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial drug resistance or other interventions may bias IBD-based estimates. In this study, we use simulations, a true I...

Full description

Bibliographic Details
Main Authors: Bing Guo, Victor Borda, Roland Laboulaye, Michele D. Spring, Mariusz Wojnarski, Brian A. Vesely, Joana C. Silva, Norman C. Waters, Timothy D. O’Connor, Shannon Takala-Harrison
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46659-0

Internet

https://doi.org/10.1038/s41467-024-46659-0

Similar Items