Highly enantioselective synthesis of (R)-1,3-butanediol via deracemization of the corresponding racemate by a whole-cell stereoinverting cascade system

Highly enantioselective synthesis of (R)-1,3-butanediol via deracemization of the corresponding racemate by a whole-cell stereoinverting cascade system

Abstract Background Deracemization, the transformation of the racemate into a single stereoisomeric product in 100% theoretical yield, is an appealing but challenging option for the asymmetric synthesis of optically pure chiral compounds as important pharmaceutical intermediates. To enhance the synt...

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Bibliographic Details
Main Authors: Han Zu, Jie Gu, Hui Zhang, Anwen Fan, Yao Nie, Yan Xu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Microbial Cell Factories
Subjects:
Stereoselectivity
(R)-1,3-butanediol
Racemate
Whole-cell catalysis
Oxidation–reduction cascade
Online Access:http://link.springer.com/article/10.1186/s12934-020-01384-3

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http://link.springer.com/article/10.1186/s12934-020-01384-3

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