lncRNA FLJ20021 regulates CDK1-mediated PANoptosis in a ZBP1-dependent manner to increase the sensitivity of laryngeal cancer-resistant cells to cisplatin

lncRNA FLJ20021 regulates CDK1-mediated PANoptosis in a ZBP1-dependent manner to increase the sensitivity of laryngeal cancer-resistant cells to cisplatin

Abstract In this study, we investigated the role of the newly discovered lncRNA FLJ20021 in laryngeal cancer (LC) and its resistance to cisplatin treatment. We initially observed elevated lncRNA FLJ20021 levels in cisplatin-resistant LC cells (Hep-2/R). To explore its function, we transfected lncRNA...

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Bibliographic Details
Main Authors: Xiaoyan Yin, Haizhong Zhang, Jingmiao Wang, Yanrui Bian, Qiaojing Jia, Zhichao Yang, Chunguang Shan
Format: Article
Language:English
Published: Springer 2024-07-01
Series:Discover Oncology
Subjects:
Laryngeal cancer
lncRNA FLJ20021
CDK1
PANoptosis
Cisplatin resistance
Online Access:https://doi.org/10.1007/s12672-024-01134-6

Internet

https://doi.org/10.1007/s12672-024-01134-6

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