Phosphorylated AKT and MAPK expression in primary tumours and in corresponding metastases and clinical outcome in colorectal cancer patients receiving irinotecan-cetuximab

Phosphorylated AKT and MAPK expression in primary tumours and in corresponding metastases and clinical outcome in colorectal cancer patients receiving irinotecan-cetuximab

<p>Abstract</p> <p>Background</p> <p>Clinical observations suggested that a non negligible proportion of patients, ranging from 40% to 70%, does not seem to benefit from the use of anti-EGFR targeted antibodies even in the absence of a mutation of the K- RAS gene. The E...

Full description

Bibliographic Details
Main Authors: Scartozzi Mario, Giampieri Riccardo, Maccaroni Elena, Mandolesi Alessandra, Biagetti Simona, Alfonsi Simona, Giustini Lucio, Loretelli Cristian, Faloppi Luca, Bittoni Alessandro, Bianconi Maristella, Del Prete Michela, Bearzi Italo, Cascinu Stefano
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Journal of Translational Medicine
Subjects:
Phosphorylated AKT
Phosphorylated MAPK
Liver metastases
Cetuximab
Colorectal cancer
K-RAS
Online Access:http://www.translational-medicine.com/content/10/1/71

Internet

http://www.translational-medicine.com/content/10/1/71

Similar Items