Profiling of H3K27Ac Reveals the Influence of Asthma on the Epigenome of the Airway Epithelium

Profiling of H3K27Ac Reveals the Influence of Asthma on the Epigenome of the Airway Epithelium

BackgroundAsthma is a chronic airway disease driven by complex genetic–environmental interactions. The role of epigenetic modifications in bronchial epithelial cells (BECs) in asthma is poorly understood.MethodsWe piloted genome-wide profiling of the enhancer-associated histone modification H3K27ac...

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Bibliographic Details
Main Authors: Peter McErlean, Audrey Kelly, Jaideep Dhariwal, Max Kirtland, Julie Watson, Ismael Ranz, Janet Smith, Alka Saxena, David J. Cousins, Antoon Van Oosterhout, Roberto Solari, Michael R. Edwards, Sebastian L. Johnston, Paul Lavender
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Genetics
Subjects:
asthma
epigenetics
H3K27ac—Histone 3 lysine 27 acetylation
chromatin
bronchial epithelial cells
lung
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.585746/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2020.585746/full

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