Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor

The dopamine D2 receptor (D2R) is known to elicit effects through activating two major signaling pathways mediated by either G proteins (Gi/o) or β-arrestins. However, the specific role of each pathway in physiological or therapeutic activities is not known with certainty. One approach to the dissec...

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Bibliographic Details
Main Authors: Lani S. Chun, Rakesh H. Vekariya, R. Benjamin Free, Yun Li, Da-Ting Lin, Ping Su, Fang Liu, Yoon Namkung, Stephane A. Laporte, Amy E. Moritz, Jeffrey Aubé, Kevin J. Frankowski, David R. Sibley
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
D2 dopamine receptor
functional selectivity
biased signaling
structure-activity relationship
MLS1547
quinoline
Online Access:http://journal.frontiersin.org/article/10.3389/fnsyn.2018.00002/full

Internet

http://journal.frontiersin.org/article/10.3389/fnsyn.2018.00002/full

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