Significance of Liver Zonation in Hepatocellular Carcinoma

Significance of Liver Zonation in Hepatocellular Carcinoma

Liver zonation is fundamental to normal liver function, and numerous studies have investigated the microstructure of normal liver lobules. However, only a few studies have explored the zonation signature in hepatocellular carcinoma (HCC). In this study, we investigated the significance of liver zona...

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Bibliographic Details
Main Authors: Shizhe Yu, Jie Gao, Haoren Wang, Long Liu, Xudong Liu, Yuantong Xu, Jihua Shi, Wenzhi Guo, Shuijun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hepatocellular carcinoma
liver zonation
tumor dedifferentiation
single-cell RNA sequence
multiplex immunofluorescence
PON1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.806408/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.806408/full

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