CARbodies: Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors

CARbodies: Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors

A human single-chain variable fragment (scFv) antibody library was expressed on the surface of human T cells after transduction with lentiviral vectors (LVs). The repertoire was fused to a first-generation T cell receptor ζ (TCRζ)-based chimeric antigen receptor (CAR). We used this library to isolat...

Full description

Bibliographic Details
Main Authors: Vanesa Alonso-Camino, David Sánchez-Martín, Marta Compte, Natalia Nuñez-Prado, Rosa M Diaz, Richard Vile, Luis Alvarez-Vallina
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
adoptive cell therapy
antibody
chimeric antigen receptor
repertoire selection
tumor-associated antigens
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301512

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116301512

Similar Items