Loss of α6β4 Integrin-Mediated Hemidesmosomes Promotes Prostate Epithelial Cell Migration by Stimulating Focal Adhesion Dynamics

Loss of α6β4 Integrin-Mediated Hemidesmosomes Promotes Prostate Epithelial Cell Migration by Stimulating Focal Adhesion Dynamics

Epithelial cell adhesion is mediated by actin cytoskeleton-linked focal adhesions (FAs) and intermediate filament-associated hemidesmosomes (HDs). HDs are formed by α6β4-integrins and mediate stable anchoring to the extracellular matrix (ECM) while FAs containing β1-integrins regulate cell migration...

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Bibliographic Details
Main Authors: Anette Schmidt, Mika Kaakinen, Tomasz Wenta, Aki Manninen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
α6β4-integrins
hemidesmosome
focal adhesion regulation
prostate cancer
CRISPR/Cas9 knock-in
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.886569/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.886569/full

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