Immunogenicity of a DNA-Based Sindbis Replicon Expressing Crimean–Congo Hemorrhagic Fever Virus Nucleoprotein

Crimean–Congo hemorrhagic fever virus (CCHFV) infrequently causes hemorrhagic fever in humans with a case fatality rate of 30%. Currently, there is neither an internationally approved antiviral drug nor a vaccine against the virus. A replicon based on the Sindbis virus vector encoding the complete o...

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Bibliographic Details
Main Authors: Thomas Tipih, Mark Heise, Felicity Jane Burt
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/9/12/1491