Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes
Combinatorial and modular methods to synthesize small molecule modulators of protein activity have proven to be powerful tools in the development of new drug-like molecules. Over the past decade, these methodologies have been adapted toward utilization in the development of activity- and affinity-ba...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.644811/full |
| _version_ | 1818418190391181312 |
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| author | Antonie J. van der Zouwen Martin D. Witte |
| author_facet | Antonie J. van der Zouwen Martin D. Witte |
| author_sort | Antonie J. van der Zouwen |
| collection | DOAJ |
| description | Combinatorial and modular methods to synthesize small molecule modulators of protein activity have proven to be powerful tools in the development of new drug-like molecules. Over the past decade, these methodologies have been adapted toward utilization in the development of activity- and affinity-based chemical probes, as well as in chemoproteomic profiling. In this review, we will discuss how methods like multicomponent reactions, DNA-encoded libraries, phage displays, and others provide new ways to rapidly screen novel chemical probes against proteins of interest. |
| first_indexed | 2024-12-14T12:18:44Z |
| format | Article |
| id | doaj.art-7cc220ea22b44999af5020ab0bac7c8b |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-14T12:18:44Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-7cc220ea22b44999af5020ab0bac7c8b2022-12-21T23:01:34ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-04-01910.3389/fchem.2021.644811644811Modular Approaches to Synthesize Activity- and Affinity-Based Chemical ProbesAntonie J. van der ZouwenMartin D. WitteCombinatorial and modular methods to synthesize small molecule modulators of protein activity have proven to be powerful tools in the development of new drug-like molecules. Over the past decade, these methodologies have been adapted toward utilization in the development of activity- and affinity-based chemical probes, as well as in chemoproteomic profiling. In this review, we will discuss how methods like multicomponent reactions, DNA-encoded libraries, phage displays, and others provide new ways to rapidly screen novel chemical probes against proteins of interest.https://www.frontiersin.org/articles/10.3389/fchem.2021.644811/fullchemical probe designactivity-based probeaffinity-based probeprotein profilingDNA-templatedSuFEx |
| spellingShingle | Antonie J. van der Zouwen Martin D. Witte Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes Frontiers in Chemistry chemical probe design activity-based probe affinity-based probe protein profiling DNA-templated SuFEx |
| title | Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes |
| title_full | Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes |
| title_fullStr | Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes |
| title_full_unstemmed | Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes |
| title_short | Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes |
| title_sort | modular approaches to synthesize activity and affinity based chemical probes |
| topic | chemical probe design activity-based probe affinity-based probe protein profiling DNA-templated SuFEx |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2021.644811/full |
| work_keys_str_mv | AT antoniejvanderzouwen modularapproachestosynthesizeactivityandaffinitybasedchemicalprobes AT martindwitte modularapproachestosynthesizeactivityandaffinitybasedchemicalprobes |