Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression

Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression

Uncontrolled accumulation of pulmonary artery smooth muscle cells (PASMCs) to the distal pulmonary arterioles (PAs) is one of the major characteristics of pulmonary hypertension (PH). Cellular senescence contributes to aging and lung diseases associated with PH and links to PH progression. However,...

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Bibliographic Details
Main Authors: Priscilla Kyi, Kathryn Hendee, Tendai Hunyenyiwa, Kienna Matus, Tadanori Mammoto, Akiko Mammoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Medicine
Subjects:
pulmonary hypertension
hypoxia
endothelial cell
senescence
TWIST1
PDGFB
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.908639/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.908639/full

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