Discovery and Clinical Evaluation of MK‐8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release

Discovery and Clinical Evaluation of MK‐8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release

Background Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we describe the preclinical and clinical results of a trans...

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Bibliographic Details
Main Authors: Clayton D. Knox, Pieter‐Jan deKam, Karim Azer, Peggy Wong, Antwan G. Ederveen, Diane Shevell, Christopher Morabito, Alan G. Meehan, Wen Liu, Tom Reynders, Jean Francois Denef, Anna Mitselos, Daniel Jonathan, David E. Gutstein, Kaushik Mitra, Shu Yu Sun, Michael Man‐Chu Lo, Doris Cully, Amjad Ali
Format: Article
Language:English
Published: Wiley 2016-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
blood pressure
nitrate
nitrate tolerance
nitric oxide
vasodilation
Online Access:https://doi.org/10.1161/JAHA.116.003493

Internet

https://doi.org/10.1161/JAHA.116.003493

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