CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways

CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways

Summary: Osteoporosis is a prevalent systemic metabolic disease in modern society, in which patients often suffer from bone loss due to over-activation of osteoclasts. Currently, amelioration of bone loss through modulation of osteoclast activity is a major therapeutic strategy. Ataxia telangiectasi...

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Bibliographic Details
Main Authors: Minglian Xu, Dezhi Song, Xiaoxiao Xie, Yiwu Qin, Jian Huang, Chaofeng Wang, Junchun Chen, Yuangang Su, Jiake Xu, Jinmin Zhao, Qian Liu
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Biological sciences
Molecular physiology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223018370

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http://www.sciencedirect.com/science/article/pii/S2589004223018370

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