Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies

Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies

Abstract Background Metabolic reprogramming is a central feature in many cancer subtypes and a hallmark of cancer. Many therapeutic strategies attempt to exploit this feature, often having unintended side effects on normal metabolic programs and limited efficacy due to integrative nature of metaboli...

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Bibliographic Details
Main Authors: Daniel F. Liefwalker, Meital Ryan, Zhichao Wang, Khyatiben V. Pathak, Seema Plaisier, Vidhi Shah, Bobby Babra, Gabrielle S. Dewson, Ian K. Lai, Adriane R. Mosley, Patrick T. Fueger, Stephanie C. Casey, Lei Jiang, Patrick Pirrotte, Srividya Swaminathan, Rosalie C. Sears
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Cancer & Metabolism
Subjects:
c-MYC
BCR-ABL
RAS
Lymphoma
T-ALL
Cancer metabolism
Online Access:https://doi.org/10.1186/s40170-021-00263-8

Internet

https://doi.org/10.1186/s40170-021-00263-8

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