The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues

The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues

CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and stimulation by inflammatory cytokines, such as IL-12 a...

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Bibliographic Details
Main Authors: Filippo Cortesi, Gloria Delfanti, Giulia Casorati, Paolo Dellabona
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
NKT cells
CD1d
monocytes
macrophages
DC
microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02375/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02375/full

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