Oxidative stress induces MUC5AC expression through mitochondrial damage‐dependent STING signaling in human bronchial epithelial cells

Oxidative stress induces MUC5AC expression through mitochondrial damage‐dependent STING signaling in human bronchial epithelial cells

Abstract Oxidative stress increases the production of the predominant mucin MUC5AC in airway epithelial cells and is implicated in the pathogenesis of bronchial asthma and chronic obstructive pulmonary disease. Oxidative stress impairs mitochondria, releasing mitochondrial DNA into the cytoplasm and...

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Bibliographic Details
Main Authors: Yutaka Nishida, Hisako Yagi, Masaya Ota, Atsushi Tanaka, Koichiro Sato, Takaharu Inoue, Satoshi Yamada, Naoya Arakawa, Takashi Ishige, Yasuko Kobayashi, Hirokazu Arakawa, Takumi Takizawa
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:FASEB BioAdvances
Subjects:
hydrogen peroxide
mitochondria
mtDNA
MUC5AC
oxidative stress
STING
Online Access:https://doi.org/10.1096/fba.2022-00081

Internet

https://doi.org/10.1096/fba.2022-00081

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