Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques

Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques

Inflammatory macrophages are key drivers of atherosclerosis that can induce rupture-prone vulnerable plaques. Skewing the plaque macrophage population towards a more protective phenotype and reducing the occurrence of clinical events is thought to be a promising method of treating atherosclerotic pa...

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Bibliographic Details
Main Authors: Karl J. Harber, Annette E. Neele, Cindy PAA. van Roomen, Marion JJ. Gijbels, Linda Beckers, Myrthe den Toom, Bauke V. Schomakers, Daan AF. Heister, Lisa Willemsen, Guillermo R. Griffith, Kyra E. de Goede, Xanthe AMH. van Dierendonck, Myrthe E. Reiche, Aurélie Poli, Frida L-H Mogensen, Alessandro Michelucci, Sanne GS. Verberk, Helga de Vries, Michel van Weeghel, Jan Van den Bossche, Menno PJ. de Winther
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Subjects:
Itaconate
IRG1
Acod1
Immunometabolism
Atherosclerosis
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000302

Internet

http://www.sciencedirect.com/science/article/pii/S2213231724000302

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