Altering the mRNA-1273 dosing interval impacts the kinetics, quality, and magnitude of immune responses in mice

Altering the mRNA-1273 dosing interval impacts the kinetics, quality, and magnitude of immune responses in mice

For a vaccine to achieve durable immunity and optimal efficacy, many require a multi-dose primary vaccination schedule that acts to first “prime” naive immune systems and then “boost” initial immune responses by repeated immunizations (ie, prime-boost regimens). In the context of the global coronavi...

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Bibliographic Details
Main Authors: Dario Garcia-Dominguez, Carole Henry, LingZhi Ma, Hardik Jani, Nicholas J. Amato, Taylor Manning, Alec Freyn, Heather Davis, Chiaowen Joyce Hsiao, Mengying Li, Hillary Koch, Sayda Elbashir, Anthony DiPiazza, Andrea Carfi, Darin Edwards, Kapil Bahl
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
mRNA-1273
COVID-19
dosing interval
dosing regimen
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.948335/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.948335/full

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