Dysregulated Polycomb Repressive Complex 2 contributes to chronic obstructive pulmonary disease by rewiring stem cell fate

Dysregulated Polycomb Repressive Complex 2 contributes to chronic obstructive pulmonary disease by rewiring stem cell fate

Summary: Aberrant lung cell differentiation is a hallmark of many lung diseases including chronic obstructive pulmonary disease (COPD). The EZH2-containing Polycomb Repressive Complex 2 (PRC2) regulates embryonic lung stem cell fate, but its role in adult lung is obscure. Histological analysis of pa...

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Bibliographic Details
Main Authors: Aria L. Byrd, Xufeng Qu, Alexsandr Lukyanchuk, Jinpeng Liu, Fan Chen, Kassandra J. Naughton, Tanner J. DuCote, Xiulong Song, Hannah C. Bowman, Yanming Zhao, Abigail R. Edgin, Chi Wang, Jinze Liu, Christine Fillmore Brainson
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Stem Cell Reports
Subjects:
lung stem cells
Polycomb Repressive Complex
chronic obstructive pulmonary disease
organoids
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671122005422

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http://www.sciencedirect.com/science/article/pii/S2213671122005422

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