Physical Characteristics of von Willebrand Factor Binding with Platelet Glycoprotein Ibɑ Mutants at Residue 233 Causing Various Biological Functions

Physical Characteristics of von Willebrand Factor Binding with Platelet Glycoprotein Ibɑ Mutants at Residue 233 Causing Various Biological Functions

Glycoprotein (GP: HIS1-PRO265) Ibɑ is a receptor protein expressed on the surface of the platelet. Its N-terminus domain binds with the A1 domain (ASP1269-PRO1472) of its ligand protein von Willebrand factor (VWF) and plays a unique role in platelet adhesion under blood flow conditions. Single amino...

Full description

Bibliographic Details
Main Authors: Masamitsu Nakayama, Shinichi Goto, Shinya Goto
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2022-10-01
Series:TH Open
Subjects:
platelet
von willebrand factor
salt bridge
molecular dynamic
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/a-1937-9940

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/a-1937-9940

Similar Items