Utility of the Hebb–Williams Maze Paradigm for Translational Research in Fragile X Syndrome: A Direct Comparison of Mice and Humans

To generate meaningful information, translational research must employ paradigms that allow extrapolation from animal models to humans. However, few studies have evaluated translational paradigms on the basis of defined validation criteria. We outline three criteria for validating translational para...

Full description

Bibliographic Details
Main Authors: Isabelle Boutet, Charles A. Collin, Lindsey S. MacLeod, Claude Messier, Matthew R. Holahan, Elizabeth Berry-Kravis, Reno M. Gandhi, Cary S. Kogan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00099/full