Associations between polygenic risk, negative symptoms, and functional connectome topology during a working memory task in early-onset schizophrenia

Abstract Working memory (WM) deficit in schizophrenia is thought to arise from a widespread neural inefficiency. However, we do not know if this deficit results from the illness-related genetic risk and influence the symptom burden in various domains, especially in patients who have an early onset i...

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Bibliographic Details
Main Authors: Mengjie Deng, Zhening Liu, Wen Zhang, Zhipeng Wu, Hengyi Cao, Jie Yang, Lena Palaniyappan
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:npj Schizophrenia
Online Access:https://doi.org/10.1038/s41537-022-00260-w