UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer

UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer

Abstract UBR5, a HECT-domain E3 ubiquitin ligase, is an attractive therapeutic target for aggressive breast cancers. Defining the substrates of UBR5 is crucial for scientific understanding and clinical intervention. Here, we demonstrate that CDC73, a component of the RNA polymerase II-associated fac...

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Bibliographic Details
Main Authors: Gang Xiang, Shuxuan Wang, Ling Chen, Mei Song, Xiaoxu Song, Huan Wang, Pengbo Zhou, Xiaojing Ma, Jing Yu
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04914-6

Internet

https://doi.org/10.1038/s41419-022-04914-6

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