Constitutively active form of natriuretic peptide receptor 2 ameliorates experimental pulmonary arterial hypertension

Constitutively active form of natriuretic peptide receptor 2 ameliorates experimental pulmonary arterial hypertension

We recently found a constitutively active mutant of natriuretic peptide receptor 2 (caNPR2; V883M), which synthesizes larger amounts of cyclic guanosine monophosphate (cGMP) intracellularly without any ligand stimulation than existing drugs. The aim of this study was to investigate the therapeutic e...

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Main Authors: Nobutoshi Nawa, Hidekazu Ishida, Shinichi Katsuragi, Hiroki Baden, Kunihiko Takahashi, Ryota Higeno, Fumiko Torigoe, Seiko Mihara, Jun Narita, Kohji Miura, Kazufumi Nakamura, Shigetoyo Kogaki, Keiichi Ozono
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300165

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http://www.sciencedirect.com/science/article/pii/S2329050117300165

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