A Parameter Refinement Method for Ptychography Based on Deep Learning Concepts

X-ray ptychography is an advanced computational microscopy technique, which is delivering exceptionally detailed quantitative imaging of biological and nanotechnology specimens, which can be used for high-precision X-ray measurements. However, coarse parametrisation in propagation distance, position...

Full description

Bibliographic Details
Main Authors: Francesco Guzzi, George Kourousias, Alessandra Gianoncelli, Fulvio Billè, Sergio Carrato
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Condensed Matter
Subjects:
Online Access:https://www.mdpi.com/2410-3896/6/4/36
Description
Summary:X-ray ptychography is an advanced computational microscopy technique, which is delivering exceptionally detailed quantitative imaging of biological and nanotechnology specimens, which can be used for high-precision X-ray measurements. However, coarse parametrisation in propagation distance, position errors and partial coherence frequently threaten the experimental viability. In this work, we formally introduce these actors, solving the whole reconstruction as an optimisation problem. A modern deep learning framework was used to autonomously correct the setup incoherences, thus improving the quality of a ptychography reconstruction. Automatic procedures are indeed crucial to reduce the time for a reliable analysis, which has a significant impact on all the fields that use this kind of microscopy. We implemented our algorithm in our software framework, SciComPty, releasing it as open-source. We tested our system on both synthetic datasets, as well as on real data acquired at the TwinMic beamline of the Elettra synchrotron facility.
ISSN:2410-3896