Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity

Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity

The accumulation of glutamate can excessively activate the N-methyl-d-aspartate (NMDA) receptors and cause excitotoxicity. Daphnetin (Dap), a coumarin derivative, is a protein kinase inhibitor that exhibits antioxidant and neuroprotective properties. However, little is known about the neuroprotectiv...

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Bibliographic Details
Main Authors: Le Yang, Qi Yang, Kun Zhang, Yu-Jiao Li, Yu-Mei Wu, Shui-Bing Liu, Lian-He Zheng, Ming-Gao Zhao
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Molecules
Subjects:
daphnetin
excitotoxicity
neuron
apoptosis
calcium
Online Access:http://www.mdpi.com/1420-3049/19/9/14542

Internet

http://www.mdpi.com/1420-3049/19/9/14542

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