Screening for pathogenic variants in obese cohort using whole-exome sequencing

Screening for pathogenic variants in obese cohort using whole-exome sequencing

Objective·To screen mutations of key genes in the leptin-melanocyte stimulating hormone (LEP-MSH) pathway by whole-exome sequencing (WES) in the obese cohort.Methods·A total of 119 obese patients aged 17－65 years old with body mass index (BMI)≥34 kg/m2, who underwent laparoscopic sleeve gastrectomy...

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Bibliographic Details
Main Authors: WANG Jinghui, ZHANG Hong, ZHANG Rong, PENG Danfeng, YU Hairong, CHEN Xianghui, XUAN Ye, HU Cheng, GU Yunjuan
Format: Article
Language:zho
Published: Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) 2023-07-01
Series:Shanghai Jiaotong Daxue xuebao. Yixue ban
Subjects:
obesity
whole-exome sequencing (wes)
leptin-melanocyte stimulating hormone pathway
gene mutation
Online Access:https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-7-882.shtml

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https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-7-882.shtml

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