Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations

Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations

Abstract Background The genetic architectures of colorectal cancer are distinct across different populations. To date, the majority of polygenic risk scores (PRSs) are derived from European (EUR) populations, which limits their accurate extrapolation to other populations. Here, we aimed to generate...

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Bibliographic Details
Main Authors: Junyi Xin, Mulong Du, Dongying Gu, Kewei Jiang, Mengyun Wang, Mingjuan Jin, Yeting Hu, Shuai Ben, Silu Chen, Wei Shao, Shuwei Li, Haiyan Chu, Linjun Zhu, Chen Li, Kun Chen, Kefeng Ding, Zhengdong Zhang, Hongbing Shen, Meilin Wang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Genome Medicine
Subjects:
Colorectal cancer
East Asian
European
Polygenic risk score
Lifestyle
Online Access:https://doi.org/10.1186/s13073-023-01156-9

Internet

https://doi.org/10.1186/s13073-023-01156-9

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