Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessiv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2023-01-01
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| Series: | Cell Stress |
| Subjects: | |
| Online Access: | http://www.cell-stress.com/researcharticles/2023a-castedo-cell-stress/ |