Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessiv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2023-01-01
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| Series: | Cell Stress |
| Subjects: | |
| Online Access: | http://www.cell-stress.com/researcharticles/2023a-castedo-cell-stress/ |
| _version_ | 1828055836819193856 |
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| author | Maria Castedo Antoine Lafarge Guido Kroemer |
| author_facet | Maria Castedo Antoine Lafarge Guido Kroemer |
| author_sort | Maria Castedo |
| collection | DOAJ |
| description | The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhibition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging. |
| first_indexed | 2024-04-10T20:45:57Z |
| format | Article |
| id | doaj.art-7d0a92c66ca14aaea92abff2bc1bacc8 |
| institution | Directory Open Access Journal |
| issn | 2523-0204 |
| language | English |
| last_indexed | 2024-04-10T20:45:57Z |
| publishDate | 2023-01-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Cell Stress |
| spelling | doaj.art-7d0a92c66ca14aaea92abff2bc1bacc82023-01-24T08:18:21ZengShared Science Publishers OGCell Stress2523-02042023-01-01711610.15698/cst2023.01.275Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and deathMaria Castedo0Antoine Lafarge1Guido Kroemer2Equipe 11 labellisée par la Ligue contre le Cancer, Université de Paris Cité, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France.Equipe 11 labellisée par la Ligue contre le Cancer, Université de Paris Cité, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France.Equipe 11 labellisée par la Ligue contre le Cancer, Université de Paris Cité, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France.The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhibition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging.http://www.cell-stress.com/researcharticles/2023a-castedo-cell-stress/parp1 inhibitiondna damageparthanatoscancerneurological diseasesagingcellular stress response |
| spellingShingle | Maria Castedo Antoine Lafarge Guido Kroemer Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death Cell Stress parp1 inhibition dna damage parthanatos cancer neurological diseases aging cellular stress response |
| title | Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death |
| title_full | Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death |
| title_fullStr | Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death |
| title_full_unstemmed | Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death |
| title_short | Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death |
| title_sort | poly adp ribose polymerase 1 and its ambiguous role in cellular life and death |
| topic | parp1 inhibition dna damage parthanatos cancer neurological diseases aging cellular stress response |
| url | http://www.cell-stress.com/researcharticles/2023a-castedo-cell-stress/ |
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