Targeting the Negative Feedback of Adenosine‐A2AR Metabolic Pathway by a Tailored Nanoinhibitor for Photothermal Immunotherapy

Targeting the Negative Feedback of Adenosine‐A2AR Metabolic Pathway by a Tailored Nanoinhibitor for Photothermal Immunotherapy

Abstract The metabolite adenosine plays an important immunosuppressive role in the tumor microenvironment (TME) through its ligation with the metabolic checkpoint adenosine 2A receptor (A2AR). Here, an adenosine‐A2AR negative feedback pathway is highlighted during photothermal‐induced immunogenic ce...

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Bibliographic Details
Main Authors: Yiqiong Liu, Ying Liu, Dailin Xu, Jie Zang, Xiao Zheng, Yuge Zhao, Yan Li, Ruiqing He, Shuangrong Ruan, Haiqing Dong, Jingjing Gu, Yan Yang, Qian Cheng, Yongyong Li
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Advanced Science
Subjects:
adenosine
adenosine 2A receptor metabolic checkpoint
immunogenic cell death
negative feedback
polydopamine nanoparticles
Online Access:https://doi.org/10.1002/advs.202104182

Internet

https://doi.org/10.1002/advs.202104182

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