Identification of an Immunogenic Broadly Inhibitory Surface Epitope of the <named-content content-type="genus-species">Plasmodium vivax</named-content> Duffy Binding Protein Ligand Domain

Identification of an Immunogenic Broadly Inhibitory Surface Epitope of the <named-content content-type="genus-species">Plasmodium vivax</named-content> Duffy Binding Protein Ligand Domain

ABSTRACT The Plasmodium vivax Duffy binding protein region II (DBPII) is a vital ligand for the parasite’s invasion of reticulocytes, thereby making this molecule an attractive vaccine candidate against vivax malaria. However, strain-specific immunity due to DBPII allelic variation in Bc epitopes ma...

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Bibliographic Details
Main Authors: Miriam T. George, Jesse L. Schloegel, Francis B. Ntumngia, Samantha J. Barnes, Christopher L. King, Joanne L. Casey, Michael Foley, John H. Adams
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mSphere
Subjects:
DBPII
Plasmodium vivax
epitope mapping
malaria
vaccine
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00194-19

Internet

https://journals.asm.org/doi/10.1128/mSphere.00194-19

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