Structural basis of promiscuous substrate transport by Organic Cation Transporter 1

Structural basis of promiscuous substrate transport by Organic Cation Transporter 1

Abstract Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the efficacy and safety of compounds transported by OCT1, such as those used for cardiovascular, oncological, and psycholo...

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Bibliographic Details
Main Authors: Yi C. Zeng, Meghna Sobti, Ada Quinn, Nicola J. Smith, Simon H. J. Brown, Jamie I. Vandenberg, Renae M. Ryan, Megan L. O’Mara, Alastair G. Stewart
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42086-9

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https://doi.org/10.1038/s41467-023-42086-9

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