Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys.

Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys.

The Block 2 region of the merozoite surface protein-1 (MSP-1) of Plasmodium falciparum has been identified as a target of protective immunity by a combination of seroepidemiology and parasite population genetics. Immunogenicity studies in small animals and Aotus monkeys were used to determine the ef...

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Bibliographic Details
Main Authors: David R Cavanagh, Clemens H M Kocken, John H White, Graeme J M Cowan, Kay Samuel, Martin A Dubbeld, Annemarie Voorberg-van der Wel, Alan W Thomas, Jana S McBride, David E Arnot
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3885447?pdf=render

Internet

http://europepmc.org/articles/PMC3885447?pdf=render

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