Development of caspase-3-selective activity-based probes for PET imaging of apoptosis

Development of caspase-3-selective activity-based probes for PET imaging of apoptosis

Abstract Background The cysteine-aspartic acid protease caspase-3 is recognized as the main executioner of apoptosis in cells responding to specific extrinsic and intrinsic stimuli. Caspase-3 represents an interesting biomarker to evaluate treatment response, as many cancer therapies exert their eff...

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Bibliographic Details
Main Authors: Louis Lauwerys, Lucas Beroske, Angelo Solania, Christel Vangestel, Alan Miranda, Nele Van Giel, Karuna Adhikari, Anne-Marie Lambeir, Leonie wyffels, Dennis Wolan, Pieter Van der Veken, Filipe Elvas
Format: Article
Language:English
Published: SpringerOpen 2024-08-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Caspase-3
Apoptosis imaging
Activity-based probes
Radiotracer
PET imaging
Online Access:https://doi.org/10.1186/s41181-024-00291-x

Internet

https://doi.org/10.1186/s41181-024-00291-x

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