The regulatory function of sphingosine-1-phosphate signaling axis on regulatory T cells in colorectal cancer
In tumors associated with inflammation such as inflammatory bowel disease (IBD) and colorectal cancer (CRC), high numbers of regulatory T cells (Tregs) are associated with both favorable and poor prognoses. The functions of Tregs in CRC remain elusive and have yet to be clearly defined. With new evi...
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| Format: | Article |
| Language: | English |
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AIMS Press
2015-02-01
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| Series: | AIMS Molecular Science |
| Subjects: | |
| Online Access: | http://www.aimspress.com/article/10.3934/molsci.2015.1.34/fulltext.html |
| _version_ | 1828369211184906240 |
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| author | Andrew V. Nguyen Yuan-Yuan Wu Elaine Y. Lin |
| author_facet | Andrew V. Nguyen Yuan-Yuan Wu Elaine Y. Lin |
| author_sort | Andrew V. Nguyen |
| collection | DOAJ |
| description | In tumors associated with inflammation such as inflammatory bowel disease (IBD) and colorectal cancer (CRC), high numbers of regulatory T cells (Tregs) are associated with both favorable and poor prognoses. The functions of Tregs in CRC remain elusive and have yet to be clearly defined. With new evidence supporting many subsets of Tregs, the research on the development and functions of these cells has begun to come to fruition. The sphingosine 1 phosphate (S1P) pathway was recently reported to regulate the development and function of regulatory T cells. This pathway may shine new light into the pleiotropic nature of these cells in cancer. In this review, we will examine current literature on the many functions of Tregs in CRC and highlight the significance of the S1P signaling pathway in Treg development/function with the implication of novel therapeutic strategies in treatment of CRC patients. |
| first_indexed | 2024-04-14T06:20:36Z |
| format | Article |
| id | doaj.art-7d19a95971b3452997dbb607aaadc056 |
| institution | Directory Open Access Journal |
| issn | 2372-028X 2372-0301 |
| language | English |
| last_indexed | 2024-04-14T06:20:36Z |
| publishDate | 2015-02-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Molecular Science |
| spelling | doaj.art-7d19a95971b3452997dbb607aaadc0562022-12-22T02:08:03ZengAIMS PressAIMS Molecular Science2372-028X2372-03012015-02-0121344710.3934/molsci.2015.1.34The regulatory function of sphingosine-1-phosphate signaling axis on regulatory T cells in colorectal cancerAndrew V. Nguyen0Yuan-Yuan Wu1Elaine Y. Lin2Department of Biological Sciences and Geology, The City University of New York-Queensborough, 222 56th Avenue, Room 202 Medical Arts, Bayside, NY, USAMRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UKDepartment of Medicine, Cancer Center Albert Einstein College of Medicine, 1300 Morris Park, Bronx, NY, USA. Current address: Cell, Developmental & Cancer Biology. Oregon Health & Science University. Room 5341 Richard Jones Hall. 3181 SW Sam Jackson Park Rd. Portland, OR. 97239-3098, USAIn tumors associated with inflammation such as inflammatory bowel disease (IBD) and colorectal cancer (CRC), high numbers of regulatory T cells (Tregs) are associated with both favorable and poor prognoses. The functions of Tregs in CRC remain elusive and have yet to be clearly defined. With new evidence supporting many subsets of Tregs, the research on the development and functions of these cells has begun to come to fruition. The sphingosine 1 phosphate (S1P) pathway was recently reported to regulate the development and function of regulatory T cells. This pathway may shine new light into the pleiotropic nature of these cells in cancer. In this review, we will examine current literature on the many functions of Tregs in CRC and highlight the significance of the S1P signaling pathway in Treg development/function with the implication of novel therapeutic strategies in treatment of CRC patients.http://www.aimspress.com/article/10.3934/molsci.2015.1.34/fulltext.htmlregulatory T Cellscolorectal cancersphingosine-1 phosphatetherapeutic drugs |
| spellingShingle | Andrew V. Nguyen Yuan-Yuan Wu Elaine Y. Lin The regulatory function of sphingosine-1-phosphate signaling axis on regulatory T cells in colorectal cancer AIMS Molecular Science regulatory T Cells colorectal cancer sphingosine-1 phosphate therapeutic drugs |
| title | The regulatory function of sphingosine-1-phosphate signaling axis on regulatory T cells in colorectal cancer |
| title_full | The regulatory function of sphingosine-1-phosphate signaling axis on regulatory T cells in colorectal cancer |
| title_fullStr | The regulatory function of sphingosine-1-phosphate signaling axis on regulatory T cells in colorectal cancer |
| title_full_unstemmed | The regulatory function of sphingosine-1-phosphate signaling axis on regulatory T cells in colorectal cancer |
| title_short | The regulatory function of sphingosine-1-phosphate signaling axis on regulatory T cells in colorectal cancer |
| title_sort | regulatory function of sphingosine 1 phosphate signaling axis on regulatory t cells in colorectal cancer |
| topic | regulatory T Cells colorectal cancer sphingosine-1 phosphate therapeutic drugs |
| url | http://www.aimspress.com/article/10.3934/molsci.2015.1.34/fulltext.html |
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