Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge
CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies confirmed that aberrant cellular senescence-associated mitochondria dysfunction and metabolic reprogramming had bee...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/11/6064 |
| _version_ | 1797493171347783680 |
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| author | Wiwin Is Effendi Tatsuya Nagano |
| author_facet | Wiwin Is Effendi Tatsuya Nagano |
| author_sort | Wiwin Is Effendi |
| collection | DOAJ |
| description | CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies confirmed that aberrant cellular senescence-associated mitochondria dysfunction and metabolic reprogramming had been identified in different IPF lung cells (alveolar epithelial cells, alveolar endothelial cells, fibroblasts, and macrophages). Here, we reviewed the role of the CTGF in IPF lung cells to mediate anomalous senescence-related metabolic mechanisms that support the fibrotic environment in IPF. |
| first_indexed | 2024-03-10T01:16:11Z |
| format | Article |
| id | doaj.art-7d19bf6ed24d451887b599c3d59d106e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:16:11Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7d19bf6ed24d451887b599c3d59d106e2023-11-23T14:08:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012311606410.3390/ijms23116064Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the BridgeWiwin Is Effendi0Tatsuya Nagano1Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, IndonesiaDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanCTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies confirmed that aberrant cellular senescence-associated mitochondria dysfunction and metabolic reprogramming had been identified in different IPF lung cells (alveolar epithelial cells, alveolar endothelial cells, fibroblasts, and macrophages). Here, we reviewed the role of the CTGF in IPF lung cells to mediate anomalous senescence-related metabolic mechanisms that support the fibrotic environment in IPF.https://www.mdpi.com/1422-0067/23/11/6064CTGFpro-fibroticmitochondria dysfunctionmetabolic dysregulationsenescencechronic respiratory diseases |
| spellingShingle | Wiwin Is Effendi Tatsuya Nagano Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge International Journal of Molecular Sciences CTGF pro-fibrotic mitochondria dysfunction metabolic dysregulation senescence chronic respiratory diseases |
| title | Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge |
| title_full | Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge |
| title_fullStr | Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge |
| title_full_unstemmed | Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge |
| title_short | Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge |
| title_sort | connective tissue growth factor in idiopathic pulmonary fibrosis breaking the bridge |
| topic | CTGF pro-fibrotic mitochondria dysfunction metabolic dysregulation senescence chronic respiratory diseases |
| url | https://www.mdpi.com/1422-0067/23/11/6064 |
| work_keys_str_mv | AT wiwiniseffendi connectivetissuegrowthfactorinidiopathicpulmonaryfibrosisbreakingthebridge AT tatsuyanagano connectivetissuegrowthfactorinidiopathicpulmonaryfibrosisbreakingthebridge |