Rare Alleles and Signatures of Selection on the Immunodominant Domains of Pfs230 and Pfs48/45 in Malaria Parasites From Western Kenya

Rare Alleles and Signatures of Selection on the Immunodominant Domains of Pfs230 and Pfs48/45 in Malaria Parasites From Western Kenya

Background: Malaria elimination and eradication efforts can be advanced by including transmission-blocking or reducing vaccines (TBVs) alongside existing interventions. Key transmission-blocking vaccine candidates, such as Pfs230 domain one and Pfs48/45 domain 3, should be genetically stable to avoi...

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Bibliographic Details
Main Authors: Kevin O. Ochwedo, Fredrick O. Ariri, Wilfred O. Otambo, Edwin O. Magomere, Isaiah Debrah, Shirley A. Onyango, Pauline W. Orondo, Harrysone E. Atieli, Sidney O. Ogolla, Antony C. A. Otieno, Wolfgang R. Mukabana, Andrew K. Githeko, Ming-Chieh Lee, Guiyun Yan, Daibin Zhong, James W. Kazura
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Genetics
Subjects:
Pfs230
Pfs48/45
transmission blocking vaccines
genetic diversity
evolutionary forces
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.867906/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.867906/full

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