Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity
Abstract Within-person, moment-to-moment, variability in behavior increases with advancing adult age, potentially reflecting the influence of reduced structural and neurochemical brain integrity, especially that of the dopaminergic system. We examined the role of dopamine D2 receptor (D2DR) availabi...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-00106-y |
| _version_ | 1819117208901517312 |
|---|---|
| author | Saana M. Korkki Goran Papenberg Nina Karalija Douglas D. Garrett Katrine Riklund Martin Lövdén Ulman Lindenberger Lars Nyberg Lars Bäckman |
| author_facet | Saana M. Korkki Goran Papenberg Nina Karalija Douglas D. Garrett Katrine Riklund Martin Lövdén Ulman Lindenberger Lars Nyberg Lars Bäckman |
| author_sort | Saana M. Korkki |
| collection | DOAJ |
| description | Abstract Within-person, moment-to-moment, variability in behavior increases with advancing adult age, potentially reflecting the influence of reduced structural and neurochemical brain integrity, especially that of the dopaminergic system. We examined the role of dopamine D2 receptor (D2DR) availability, grey-, and white-matter integrity, for between-person differences in cognitive variability in a large sample of healthy older adults (n = 181; 64–68 years) from the Cognition, Brain, and Aging (COBRA) study. Intra-individual variability (IIV) in cognition was measured as across-trial variability in participants’ response times for tasks assessing perceptual speed and working memory, as well as for a control task of motor speed. Across the whole sample, no associations of D2DR availability, or grey- and white-matter integrity, to IIV were observed. However, within-person variability in cognition was increased in two subgroups of individuals displaying low mean-level cognitive performance, one of which was characterized by low subcortical and cortical D2DR availability. In this latter group, fronto-striatal D2DR availability correlated negatively with within-person variability in cognition. This finding suggests that the influence of D2DR availability on cognitive variability may be more easily disclosed among individuals with low dopamine-system integrity, highlighting the benefits of large-scale studies for delineating heterogeneity in brain-behavior associations in older age. |
| first_indexed | 2024-12-22T05:29:20Z |
| format | Article |
| id | doaj.art-7d1bcc573392478ebd69783a8a4f0d0e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-22T05:29:20Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7d1bcc573392478ebd69783a8a4f0d0e2022-12-21T18:37:30ZengNature PortfolioScientific Reports2045-23222021-10-0111111210.1038/s41598-021-00106-yFronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integritySaana M. Korkki0Goran Papenberg1Nina Karalija2Douglas D. Garrett3Katrine Riklund4Martin Lövdén5Ulman Lindenberger6Lars Nyberg7Lars Bäckman8Aging Research Center, Karolinska Institute and Stockholm UniversityAging Research Center, Karolinska Institute and Stockholm UniversityDepartment of Radiation Sciences, Diagnostic Radiology, Umeå UniversityCenter for Lifespan Psychology, Max Planck Institute for Human DevelopmentDepartment of Radiation Sciences, Diagnostic Radiology, Umeå UniversityDepartment of Psychology, University of GothenburgCenter for Lifespan Psychology, Max Planck Institute for Human DevelopmentDepartment of Radiation Sciences, Diagnostic Radiology, Umeå UniversityAging Research Center, Karolinska Institute and Stockholm UniversityAbstract Within-person, moment-to-moment, variability in behavior increases with advancing adult age, potentially reflecting the influence of reduced structural and neurochemical brain integrity, especially that of the dopaminergic system. We examined the role of dopamine D2 receptor (D2DR) availability, grey-, and white-matter integrity, for between-person differences in cognitive variability in a large sample of healthy older adults (n = 181; 64–68 years) from the Cognition, Brain, and Aging (COBRA) study. Intra-individual variability (IIV) in cognition was measured as across-trial variability in participants’ response times for tasks assessing perceptual speed and working memory, as well as for a control task of motor speed. Across the whole sample, no associations of D2DR availability, or grey- and white-matter integrity, to IIV were observed. However, within-person variability in cognition was increased in two subgroups of individuals displaying low mean-level cognitive performance, one of which was characterized by low subcortical and cortical D2DR availability. In this latter group, fronto-striatal D2DR availability correlated negatively with within-person variability in cognition. This finding suggests that the influence of D2DR availability on cognitive variability may be more easily disclosed among individuals with low dopamine-system integrity, highlighting the benefits of large-scale studies for delineating heterogeneity in brain-behavior associations in older age.https://doi.org/10.1038/s41598-021-00106-y |
| spellingShingle | Saana M. Korkki Goran Papenberg Nina Karalija Douglas D. Garrett Katrine Riklund Martin Lövdén Ulman Lindenberger Lars Nyberg Lars Bäckman Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity Scientific Reports |
| title | Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity |
| title_full | Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity |
| title_fullStr | Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity |
| title_full_unstemmed | Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity |
| title_short | Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity |
| title_sort | fronto striatal dopamine d2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity |
| url | https://doi.org/10.1038/s41598-021-00106-y |
| work_keys_str_mv | AT saanamkorkki frontostriataldopamined2receptoravailabilityisassociatedwithcognitivevariabilityinolderindividualswithlowdopamineintegrity AT goranpapenberg frontostriataldopamined2receptoravailabilityisassociatedwithcognitivevariabilityinolderindividualswithlowdopamineintegrity AT ninakaralija frontostriataldopamined2receptoravailabilityisassociatedwithcognitivevariabilityinolderindividualswithlowdopamineintegrity AT douglasdgarrett frontostriataldopamined2receptoravailabilityisassociatedwithcognitivevariabilityinolderindividualswithlowdopamineintegrity AT katrineriklund frontostriataldopamined2receptoravailabilityisassociatedwithcognitivevariabilityinolderindividualswithlowdopamineintegrity AT martinlovden frontostriataldopamined2receptoravailabilityisassociatedwithcognitivevariabilityinolderindividualswithlowdopamineintegrity AT ulmanlindenberger frontostriataldopamined2receptoravailabilityisassociatedwithcognitivevariabilityinolderindividualswithlowdopamineintegrity AT larsnyberg frontostriataldopamined2receptoravailabilityisassociatedwithcognitivevariabilityinolderindividualswithlowdopamineintegrity AT larsbackman frontostriataldopamined2receptoravailabilityisassociatedwithcognitivevariabilityinolderindividualswithlowdopamineintegrity |