Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities

Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities

Abstract Background The biguanide drug metformin is a safe and widely prescribed drug for type 2 diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role of metformin in the prevention and treatment of cancer including colorectal cancer (CRC). However, the “m...

Full description

Bibliographic Details
Main Authors: Barbora Salovska, Erli Gao, Sophia Müller‐Dott, Wenxue Li, Carlos Chacon Cordon, Shisheng Wang, Aurelien Dugourd, George Rosenberger, Julio Saez‐Rodriguez, Yansheng Liu
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Clinical and Translational Medicine
Subjects:
colorectal cancer
DIA mass spectrometry
drug synergy
kinase activity analysis
metformin
network analysis
Online Access:https://doi.org/10.1002/ctm2.1179

Internet

https://doi.org/10.1002/ctm2.1179

Similar Items