Metabolic engineering of Pichia pastoris for myo-inositol production by dynamic regulation of central metabolism

Metabolic engineering of Pichia pastoris for myo-inositol production by dynamic regulation of central metabolism

Abstract Background The methylotrophic budding yeast Pichia pastoris GS115 is a powerful expression system and hundreds of heterologous proteins have been successfully expressed in this strain. Recently, P. pastoris has also been exploited as an attractive cell factory for the production of high-val...

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Bibliographic Details
Main Authors: Qiquan Zhang, Xiaolu Wang, Huiying Luo, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Xiaoyun Su, Huoqing Huang, Bin Yao, Yingguo Bai, Jie Zhang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Microbial Cell Factories
Subjects:
Myo-inositol
Pichia pastoris
Metabolic engineering
Dynamic regulation
High-cell-density fermentation
Online Access:https://doi.org/10.1186/s12934-022-01837-x

Internet

https://doi.org/10.1186/s12934-022-01837-x

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