Dexmedetomidine ameliorates hepatic ischemia reperfusion injury via modulating SIRT3 mediated mitochondrial quality control

Dexmedetomidine ameliorates hepatic ischemia reperfusion injury via modulating SIRT3 mediated mitochondrial quality control

Abstract Ischaemia-reperfusion (IR) damage is an inevitable adverse effect of liver surgery. Recent research has found that IR damage is involved in severe mitochondrial dysfunction. Mitochondrial biosynthesis and dynamics control mitochondrial mass, distribution, and function. Sirtuin 3 (SIRT3) is...

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Bibliographic Details
Main Authors: Xiaqing Ning, Jilang Tang, Xueqin Li, Jiaqi Wang, Fan Zhai, Congcong Jiang, Shixia Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Dexmedetomidine
Ischemia-reperfusion
Liver
Mitochondrial biogenesis
Mitochondrial dynamics
SIRT3
Online Access:https://doi.org/10.1038/s41598-025-90069-1

Internet

https://doi.org/10.1038/s41598-025-90069-1

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