1α,25(OH)2D3 attenuates IL-6 and IL-1β-mediated inflammatory responses in macrophage conditioned medium-stimulated human white preadipocytes by modulating p44/42 MAPK and NF-κB signaling pathways

1α,25(OH)2D3 attenuates IL-6 and IL-1β-mediated inflammatory responses in macrophage conditioned medium-stimulated human white preadipocytes by modulating p44/42 MAPK and NF-κB signaling pathways

Abstract Background Metabolic syndrome is characterized by macrophage infiltration and inflammatory responses—metaflammation in adipose tissue. IL-6 and IL-1β could mediate the inflammatory responses in macrophage stimulated-preadipocytes by modulating MAPK and NF-κB pathways. To test this hypothesi...

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Bibliographic Details
Main Authors: Jingjing Zhu, Chen Bing, John P. H. Wilding
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Human white preadipocytes
Macrophages
IL-6
IL-1β
Inflammatory responses
relA
Online Access:http://link.springer.com/article/10.1186/s13098-019-0405-2

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http://link.springer.com/article/10.1186/s13098-019-0405-2

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