Human Microglia Synthesize Neurosteroids to Cope with Rotenone-Induced Oxidative Stress

Human Microglia Synthesize Neurosteroids to Cope with Rotenone-Induced Oxidative Stress

We obtained evidence that mouse BV2 microglia synthesize neurosteroids dynamically to modify neurosteroid levels in response to oxidative damage caused by rotenone. Here, we evaluated whether neurosteroids could be produced and altered in response to rotenone by the human microglial clone 3 (HMC3) c...

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Bibliographic Details
Main Authors: Chiara Lucchi, Alessandro Codeluppi, Monica Filaferro, Giovanni Vitale, Cecilia Rustichelli, Rossella Avallone, Jessica Mandrioli, Giuseppe Biagini
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Antioxidants
Subjects:
allopregnanolone
microglia
neuroinflammation
neurosteroids
reactive oxygen species
rotenone
Online Access:https://www.mdpi.com/2076-3921/12/4/963

Internet

https://www.mdpi.com/2076-3921/12/4/963

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