High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites

High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites

Abstract Objectives The purpose of this study was to evaluate the effect of gabapentin on Ehrlich tumor growth in Swiss mice, a highly aggressive and inflammatory tumor model. Mice were grouped into sets of 5 animals and treated from days 2 to 8 with gabapentin 30 mg/kg body weight (G30) or 100 mg/k...

Full description

Bibliographic Details
Main Authors: Plinio da Cunha Leal, Ed Carlos Rey Moura, Rachel Jorge Dino Cossetti, Johnny Ramos do Nascimento, Izabel Cristina Portela Bogéa Serra, Bruno de Paulo Ribeiro, Andre Álvares Marques Vale, Ana Paula Silva de Azevedo dos Santos, Flavia Raquel Fernandes do Nascimento, Rioko Kimiko Sakata
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Research Notes
Subjects:
Gabapentin
Tumor growth
Cytokine
Arginine
SOD
Ehrlich tumor
Online Access:http://link.springer.com/article/10.1186/s13104-019-4103-9

Internet

http://link.springer.com/article/10.1186/s13104-019-4103-9

Similar Items