High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites
Abstract Objectives The purpose of this study was to evaluate the effect of gabapentin on Ehrlich tumor growth in Swiss mice, a highly aggressive and inflammatory tumor model. Mice were grouped into sets of 5 animals and treated from days 2 to 8 with gabapentin 30 mg/kg body weight (G30) or 100 mg/k...
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-019-4103-9 |
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| author | Plinio da Cunha Leal Ed Carlos Rey Moura Rachel Jorge Dino Cossetti Johnny Ramos do Nascimento Izabel Cristina Portela Bogéa Serra Bruno de Paulo Ribeiro Andre Álvares Marques Vale Ana Paula Silva de Azevedo dos Santos Flavia Raquel Fernandes do Nascimento Rioko Kimiko Sakata |
| author_facet | Plinio da Cunha Leal Ed Carlos Rey Moura Rachel Jorge Dino Cossetti Johnny Ramos do Nascimento Izabel Cristina Portela Bogéa Serra Bruno de Paulo Ribeiro Andre Álvares Marques Vale Ana Paula Silva de Azevedo dos Santos Flavia Raquel Fernandes do Nascimento Rioko Kimiko Sakata |
| author_sort | Plinio da Cunha Leal |
| collection | DOAJ |
| description | Abstract Objectives The purpose of this study was to evaluate the effect of gabapentin on Ehrlich tumor growth in Swiss mice, a highly aggressive and inflammatory tumor model. Mice were grouped into sets of 5 animals and treated from days 2 to 8 with gabapentin 30 mg/kg body weight (G30) or 100 mg/kg body weight (G100), or normal sterile saline (control). Results The mice were euthanized on day 10. Tumor growth, tumoricidal agents and inflammatory cytokines levels were assessed. At day 10, G30 and G100 mice gained weight, but there were no differences in tumor cell count or in ascites volume. In G100, there was a reduction in arginase and an increase in SOD activities. There was an increase in IL-6 and MCP-1 levels, especially in G100, but no alterations in TNF-α. There was no direct evidence of tumor induction by gabapentin. However, the findings suggest that its use modulates immune response to a more effector and less deleterious profile, with increase in activity of anti-oxidant enzymes and in cytokines that favor activation of macrophages, which could improve the general status of the tumor host. |
| first_indexed | 2024-12-20T19:42:26Z |
| format | Article |
| id | doaj.art-7d26b48eb11d4dfb83013e6511e1ee6b |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-20T19:42:26Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-7d26b48eb11d4dfb83013e6511e1ee6b2022-12-21T19:28:30ZengBMCBMC Research Notes1756-05002019-01-011211610.1186/s13104-019-4103-9High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascitesPlinio da Cunha Leal0Ed Carlos Rey Moura1Rachel Jorge Dino Cossetti2Johnny Ramos do Nascimento3Izabel Cristina Portela Bogéa Serra4Bruno de Paulo Ribeiro5Andre Álvares Marques Vale6Ana Paula Silva de Azevedo dos Santos7Flavia Raquel Fernandes do Nascimento8Rioko Kimiko Sakata9Federal University of MaranhãoFederal University of MaranhãoFederal University of MaranhãoFederal University of MaranhãoFederal University of MaranhãoFederal University of MaranhãoFederal University of MaranhãoFederal University of MaranhãoFederal University of MaranhãoFederal University of São PauloAbstract Objectives The purpose of this study was to evaluate the effect of gabapentin on Ehrlich tumor growth in Swiss mice, a highly aggressive and inflammatory tumor model. Mice were grouped into sets of 5 animals and treated from days 2 to 8 with gabapentin 30 mg/kg body weight (G30) or 100 mg/kg body weight (G100), or normal sterile saline (control). Results The mice were euthanized on day 10. Tumor growth, tumoricidal agents and inflammatory cytokines levels were assessed. At day 10, G30 and G100 mice gained weight, but there were no differences in tumor cell count or in ascites volume. In G100, there was a reduction in arginase and an increase in SOD activities. There was an increase in IL-6 and MCP-1 levels, especially in G100, but no alterations in TNF-α. There was no direct evidence of tumor induction by gabapentin. However, the findings suggest that its use modulates immune response to a more effector and less deleterious profile, with increase in activity of anti-oxidant enzymes and in cytokines that favor activation of macrophages, which could improve the general status of the tumor host.http://link.springer.com/article/10.1186/s13104-019-4103-9GabapentinTumor growthCytokineArginineSODEhrlich tumor |
| spellingShingle | Plinio da Cunha Leal Ed Carlos Rey Moura Rachel Jorge Dino Cossetti Johnny Ramos do Nascimento Izabel Cristina Portela Bogéa Serra Bruno de Paulo Ribeiro Andre Álvares Marques Vale Ana Paula Silva de Azevedo dos Santos Flavia Raquel Fernandes do Nascimento Rioko Kimiko Sakata High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites BMC Research Notes Gabapentin Tumor growth Cytokine Arginine SOD Ehrlich tumor |
| title | High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites |
| title_full | High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites |
| title_fullStr | High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites |
| title_full_unstemmed | High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites |
| title_short | High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites |
| title_sort | high dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase il 6 and mcp 1 levels in ehrlich ascites |
| topic | Gabapentin Tumor growth Cytokine Arginine SOD Ehrlich tumor |
| url | http://link.springer.com/article/10.1186/s13104-019-4103-9 |
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